Gene Expression Profile in Major Depressive Disorder Shows Reduced Mitochondrial Biogenesis
نویسندگان
چکیده
منابع مشابه
Altered choroid plexus gene expression in major depressive disorder
Given the emergent interest in biomarkers for mood disorders, we assessed gene expression in the choroid plexus (CP), the region that produces cerebrospinal fluid (CSF), in individuals with major depressive disorder (MDD). Genes that are expressed in the CP can be secreted into the CSF and may be potential biomarker candidates. Given that we have previously shown that fibroblast growth factor f...
متن کاملMitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
BACKGROUND Mitochondria provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) in transcriptomic, proteomic, and metabolomic studies. Several mutations in mitochondrial DNA...
متن کاملprofile of major depressive disorder symptoms among patients in tehran
objectives: culture may place a differential emphasis on particular emotions. the aim of this study is to find the most frequent symptoms in patients with major depressive disorder in tehran. method: 509 patients were recruited from 5 treatment settings. the sample was used from the project of assessing psychometric properties of cidi in the iranian population. the patients were evaluated by co...
متن کاملReduced reward learning predicts outcome in major depressive disorder.
BACKGROUND Reduced reward learning might contribute to the onset and maintenance of major depressive disorder (MDD). In particular, the inability to utilize rewards to guide behavior is hypothesized to be associated with anhedonia, a core feature and potential trait marker of MDD. Few studies have investigated whether reduced reward learning normalizes with treatment and/or reward learning pred...
متن کاملPS195. Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder
Amino acids play key roles in the function of the central nervous system, and their alterations are implicated in psychiatric disorders. In the search for a biomarker for major depressive disorder (MDD), we used high-performance liquid chromatography to measure amino acids and related molecules in the cerebrospinal fluid (CSF) of 52 patients with MDD (42 depressed and 10 remitted; DSM-IV) and 5...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2016
ISSN: 1755-5930
DOI: 10.1111/cns.12568